182P Association of non-genetic factors with breast cancer risk in genetically predisposed groups of women in the UK Biobank cohort

The association between non-inherited factors, including lifestyle and the risk of breast cancer (BC) in women BC genetic makeup are only partly characterized. This study examined healthier habits genetically predisposed groups. Classification healthy was based on Cancer Research UK guidance (healthy weight, regular exercise, no use HRT for >5 years, OC use, alcohol intake<3 times/wk). Three groups were established: favorable (4 factors), intermediate (2-3 unfavorable (1 factor). contribution estimated using polygenic scores PRS 305 preselected SNPs.Cox proportional hazards regression used to assess hazard ratios (HRs) lifestyles associated with a malignant neoplasm breast. within subgroups showed lower HRs among following compared all groups: an had higher low group (HR, 1.63; 95% CI, 1.13-2.34), 1.94; 1.46-2.58), high 1.39; 1.11-1.74) reference lifestyle. Intermediate also 1.40; 1.09-1.80) 1.37; 1.12-1.68). A appeared be reduced level BC, even if at BC.